6 early pregnancy losses - looking for answers!


#1

[FONT=arial, sans-serif]Hello,

I’m new to this online community, and I am desperate for answers.

My husband (32) and I (31) have been working on starting a family for the last 4 years. Along the way we have had a total of 6 confirmed pregnancies, all of which resulted in early losses at around the 5 week mark. We have so far been able to get pregnant on our own, stimulated, with IUI and most recently with IVF and PGD/CCS.

The most recent loss was a back breaker for my husband and I. The prevailing theory going into IVF was that I have bad eggs, and we were led to believe that genetic testing is the only way to confirm whether our problem is related to the eggs or the environment. I responded well to the treatment, I had a ‘picture perfect’ lining, the embryos were top quality, and yet, we had the exact same result as all the previous pregnancies.

When we went back in to regroup after the loss, the RE told us we are now ‘off the map’ and that his recommendation is to try the ‘kitchen sink approach’ that includes a scratch test uterine biopsy, an anti-hystamine (Claritin) protocol, and steroids. Seemed convincing at the time, but we decided get some additional opinions.

So far we’ve had phone consultations with: Dr. Acacio (SoCal); Dr. Coulam (Chicago); Dr. Braverman (NY); Dr. Matzner (SoCal); Dr. Shahine (Seattle); and Dr. Patton (Portland). We also spoke with an Immunologist that consults with couples in similar situations as they look for answers after exhausting options with traditional fertility treatments. The Beers Center is also on our radar, but haven’t spoken to anyone yet officially. In reaching out to all these respected specialist, we hoped and assumed we would find a consensus but turns out more opinions equals more confusion.

We have had some preliminary immunological labwork (with Dr. Coulam late last year) and here are some of the results that have been flagged by some of the doctors we’ve spoken to:

Me:[/FONT]
[LIST]
[]NK CD56+ : 21 (retested 6 months later and dropped to 11.5)
[
]F XIII V34L DNA: Homozygous
[][FONT=arial, sans-serif]PAI-1 4G/5G DNA: [/FONT][FONT=arial]Homozygous[/FONT]
[
][FONT=arial]HPA1 a/b(L33P)[/FONT][FONT=arial, sans-serif] DNA: Heterozygous[/FONT]
[/LIST] [FONT=arial]Husband:
[LIST]
[][FONT=arial, sans-serif]Sperm DNA Fragmentation: 23% (retested 6 months later and dropped to 17%)[/FONT]
[
]BFIB -455G>A DNA: Heterozygous
[][FONT=arial, sans-serif]PAI-1 4G/5G DNA: [/FONT][FONT=arial]Heterozygous[/FONT]
[
][FONT=arial]HPA1 a/b(L33P)[/FONT][FONT=arial, sans-serif] DNA: Homozygous[/FONT]
[][FONT=arial, sans-serif]MTHFR C677T DNA: Heterozygous[/FONT]
[
][FONT=arial, sans-serif]MTHFR A1298C DNA: Heterozygous[/FONT]
[/LIST] [/FONT]
[FONT=arial]
Based on our history of losses and the lab results above here is what we’re currently thinking for our next treatment cycle.[/FONT]
[LIST]
[]Intralipids
[
]Prednisone
[]Heparin/Lovenox
[
]Low dose Aspirin
[*]FET cycle
[/LIST] [FONT=arial]
Does anyone out there have a similar history and path to success?[/FONT]


#2

Hi. Sorry to hear about your losses…
I had also a miscarriage at 6 weeks and 2 chemical pregnancies. We have a male factor (all weak) plus that dr. Braverman discovered that I have slightly elevated tnf cytokines and we have 6 hla matches. Those matches between spouses can cause those early losses since the mother’s body recognizes embryos as intruders and turns against them. Luckily, there is a medication dr. B is using called neupogen. It is expensive but not as multiple ivfs. Anyhow, I recommend you to go to dr. B. Don’t waste time with other doctors (dr. MAtzner was a complete waste of time for me. Dr. B is much more thorough and tests more). Another dr who is good is Kim-Kwak, but she is not into those hla matches. I have not had a transfer yet. Hopefully toward the end of the year, with dr. B. We put our trust in God and him. Wish you good luck and keep us posted.


#3

I have a friend who has several hla D-Q alpha matches as well. Her treatment was LIT, which she did with Dr. Garza in Mexico. She said it was cheap, and easy. She did it three times- once before BFP, and twice afterwards. She is now 17 weeks. I know you can find LIT treatments in the US, and it’s fairly easy.