6 Losses - Looking for Answers


#1

Hello,

I’m new to this online community, and I am desperate for answers.

My husband (32) and I (31) have been working on starting a family for the last 4 years. Along the way we have had a total of 6 confirmed pregnancies, all of which resulted in early losses at around the 5 week mark. We have so far been able to get pregnant on our own, stimulated, with IUI and most recently with IVF and PGD/CCS.

The most recent loss was a back breaker for my husband and I. The prevailing theory going into IVF was that I have bad eggs, and we were led to believe that genetic testing is the only way to confirm whether our problem is related to the eggs or the environment. I responded well to the treatment, I had a ‘picture perfect’ lining, the embryos were top quality, and yet, we had the exact same result as all the previous pregnancies.

When we went back in to regroup after the loss, the RE told us we are now ‘off the map’ and that his recommendation is to try the ‘kitchen sink approach’ that includes a scratch test uterine biopsy, an anti-hystamine (Claritin) protocol, and steroids. Seemed convincing at the time, but we decided get some additional opinions.

So far we’ve had phone consultations with: Dr. Acacio (SoCal); Dr. Coulam (Chicago); Dr. Braverman (NY); Dr. Matzner (SoCal); Dr. Shahine (Seattle); and Dr. Patton (Portland). We also spoke with an Immunologist that consults with couples in similar situations as they look for answers after exhausting options with traditional fertility treatments. The Beers Center is also on our radar, but haven’t spoken to anyone yet officially. In reaching out to all these respected specialist, we hoped and assumed we would find a consensus but turns out more opinions equals more confusion.

We have had some preliminary immunological labwork (with Dr. Coulam late last year) and here are some of the results that have been flagged by some of the doctors we’ve spoken to:

Me:

[LIST]
[]NK CD56+ : 21 (retested 6 months later and dropped to 11.5)
[
]F XIII V34L DNA: Homozygous
[]PAI-1 4G/5G DNA: Homozygous
[
]HPA1 a/b(L33P) DNA: Heterozygous
[/LIST] Husband:

  • Sperm DNA Fragmentation: 23% (retested 6 months later and dropped to 17%)
  • BFIB -455G>A DNA: Heterozygous
  • PAI-1 4G/5G DNA: Heterozygous
  • HPA1 a/b(L33P) DNA: Homozygous
  • MTHFR C677T DNA: Heterozygous
  • MTHFR A1298C DNA: Heterozygous

Based on our history of losses and the lab results above here is what we’re currently thinking for our next treatment cycle.

  • Intralipids
  • Prednisone
  • Heparin/Lovenox
  • Low dose Aspirin
  • FET cycle

Does anyone out there have a similar history and path to success?


#2

I have a very similar history. Most of my losses are right around 5-6 weeks as well. I seem to be on the same path as you. My last loss was after IVF with PGD. I am preparing for a September FET with intralipids, prednisone, Heparin, BA, and a few other supplements. I hope this protocol leads to success for both of us.


#3

Please read the recurrent pregnancy loss thread. In it has most of our protocols for women with recurrent losses. In addition to what you are taking I am on the following; Calcium magnesium B6/b12 combo Neevo (has the good folate) Vitamin D3 2000ui Coq-10 800mg Good luck and I’m sorry you are going through this. Rach


#4

babyaloha,

I’m so happy to see that my planned protocol aligns with yours, but at the same time I am so sad that you’ve had to endure the misery that I have.

If you don’t mind me asking, who are you working with? We’re in Portland and we’re having a hard time convincing our RE to treat us with an immunological protocol (intralipids especially). Have you had similar challenges? Also, have you been diagnosed with specific immunological issues?


#5

Hi I will be doing a fresh transfer with donor egg in a couple weeks. I have had 2 5week m/cs in the past year with donor egg. My husbands sperm dna frag is 20%. I will be adding prednisone and IVIG. I just want to find someone out there with a similar history that has gone on to have success. I will also be doing injection progesterone this time and lovenox(although i did use lovenox with last FET). My heart goes out to everyone in the recurrent loss boat. It is such a hard place to be.


#6

There is no doubt in this fact that problem of infertility arises due to female or sometimes it may also arise when any male is suffering from any weakness or may be due to any blockage he /she has to face various hurdles in their way of conceiving normally. I have treat these kind of patient who can’t conceive the baby in their initial periods.