I’m new to this online community, and I am desperate for answers.
My husband (32) and I (31) have been working on starting a family for the last 4 years. Along the way we have had a total of 6 confirmed pregnancies, all of which resulted in early losses at around the 5 week mark. We have so far been able to get pregnant on our own, stimulated, with IUI and most recently with IVF and PGD/CCS.
The most recent loss was a back breaker for my husband and I. The prevailing theory going into IVF was that I have bad eggs, and we were led to believe that genetic testing is the only way to confirm whether our problem is related to the eggs or the environment. I responded well to the treatment, I had a ‘picture perfect’ lining, the embryos were top quality, and yet, we had the exact same result as all the previous pregnancies.
When we went back in to regroup after the loss, the RE told us we are now ‘off the map’ and that his recommendation is to try the ‘kitchen sink approach’ that includes a scratch test uterine biopsy, an anti-hystamine (Claritin) protocol, and steroids. Seemed convincing at the time, but we decided get some additional opinions.
So far we’ve had phone consultations with: Dr. Acacio (SoCal); Dr. Coulam (Chicago); Dr. Braverman (NY); Dr. Matzner (SoCal); Dr. Shahine (Seattle); and Dr. Patton (Portland). We also spoke with an Immunologist that consults with couples in similar situations as they look for answers after exhausting options with traditional fertility treatments. The Beers Center is also on our radar, but haven’t spoken to anyone yet officially. In reaching out to all these respected specialist, we hoped and assumed we would find a consensus but turns out more opinions equals more confusion.
We have had some preliminary immunological labwork (with Dr. Coulam late last year) and here are some of the results that have been flagged by some of the doctors we’ve spoken to:
NK CD56+ : 21 (retested 6 months later and dropped to 11.5)
F XIII V34L DNA: Homozygous
PAI-1 4G/5G DNA: Homozygous
HPA1 a/b(L33P) DNA: Heterozygous
- Sperm DNA Fragmentation: 23% (retested 6 months later and dropped to 17%)
- BFIB -455G>A DNA: Heterozygous
- PAI-1 4G/5G DNA: Heterozygous
- HPA1 a/b(L33P) DNA: Homozygous
- MTHFR C677T DNA: Heterozygous
- MTHFR A1298C DNA: Heterozygous
Based on our history of losses and the lab results above here is what we’re currently thinking for our next treatment cycle.
- Low dose Aspirin
- FET cycle
Does anyone out there have a similar history and path to success?