After Failed IVF


#1

I am sorry if you are going through a failed IVF cycle. I went through 5 of them before finally having our miracle baby.

I just wrote an article including suggestions on what to do after you go through a failed IVF. Just thought some of you might want to check it out. (link is in sig)

Don’t give up, it is all worth it in the end!


#2

The drugs used for ovarian stimulation have mild side effects for some women, including mild bruising and soreness at the injection site, headaches, an upset stomach, and mood swings. Another side effect is ovarian hyperstimulation syndrome (OHSS.) This happens when the ovaries produce many follicles and fluid may leak from the blood vessels into the abdominal cavity and lungs. Usually this is mild and resolves on its own without treatment. In severe cases OHSS can result in very enlarged ovaries, dehydration, and large amounts of fluid in the lungs and abdomen. In less than one percent of women undergoing egg retrieval through IVF, OHSS can lead to blood clots and kidney failure, according to ASRM. This is one of the reasons that patients who are taking gonadotropins go for frequent monitoring, to make sure this is not starting to happen. If you do have a high-multiple pregnancy, defined as three or more fetuses, it is strongly suggested that you consult a physician who specializes in high-risk pregnancies, or you may want to consider reducing the number of embryos you are carrying. Both possibilities should be discussed with the doctor and your partner if you have one. Fertility doctors can moderate the amount of drugs being prescribed or alter the medication regimen if they see any indication of potential trouble. So make sure you check on this next time. Like mine in Bio tex.


#3

Our nurse at bio tex com has told us a plenty of useful & interesting things concerning pregnancy and delivery. Here’s what I got to know about the amniotic fluid which is the clear, slightly yellowish fluid within the amniotic sac that surrounds the baby in the uterus. The baby grows in this amniotic sac, surrounded by the amniotic fluid, as he learns to move his limbs, open his eyes and breathe. Amniotic fluid levels generally sit at approximately 800ml through most of the pregnancy, dropping slightly in most cases to about 600ml by the time a woman reaches the 40 week mark. The amniotic fluid has many purposes. It helps to cushion hard blows and jolts to your belly to protect the baby and it allows your baby the freedom to move while permitting symmetrical musculoskeletal development. It also maintains an even temperature so that your baby does not get too hot or too cold, even if you are extremely hot or cold. Amniotic fluid also helps your baby develop his lungs.
Thank you for the link offered. It’s awesome you took time to share all those things with others. My positive thoughts going your way.


#4

I believe if one faces multiple ivf failures then one should seek help through PGS and PGD testing. which can be performed on both fresh and frozen/thawed embryos, can identify genetically viable embryos for implantation. Any flaw in the genetic makeup of an embryo is a major cause of implantation failure. This also eliminates the prospect of a child being born with a birth defect or a genetic mutation predisposing the child to health problems. PGD screens for one specific genetic defect. It is often performed when one (or both) of the parents is known to have. or is suspected of having, a particular genetic defect that may be present in their family history. Preimplantation genetic screening (PGS) tests for many possible genetic defects (Such as Down syndrome, cystic fibrosis and the BRCA genetic mutations that predispose a mother and her children to ovarian and breast cancers.)
Anyway, thank you for sharing your ideas. Sometimes not even a dr can tell you why the iVF cycle failed. But if sth makes you suspicious, then it’s always better to take the benefits from the offered testings. I’m praying for less women going throught the failures. May the most of the ivf attempts bring people luck. Blessings.


#5

I’m with you. Quite a good option to make sure the embies are more likely to be healthy. PGD is is done on day-3 embryos which have 4-8 cells. A small cell or blastomere is removed from each embryo and is tested for the genetic abnormality. The risk of damaging the embryo at this point is very low. Only embryos that show normal results are transferred back to the uterus. Studies have shown there is no increased risk of birth defects following PGD. It is important to remember that: PGD is not 100% accurate because only one cell is tested. The technique is technically challenging and requires great expertise. Therefore, an amniocentesis or chorionic villus sampling is suggested after a pregnancy is documented. PGD testing ranges from approximately $2k to $5k and is not covered by most insurance companies. Not all IVF centers do PGD. The experimental techniques require great expertise and should only be done by qualified personnel. It is preferable if the lab performing PGD has a PhD or MD trained medical geneticist responsible for the PGD laboratory.


#6

If you are considering doing PGD, make certain the laboratory is experienced, does a large number of
cases, and is certified. Ask your doctor at the IVF clinic or the lab director the following questions:
What training has the PGD laboratory personnel who are performing the testing have?
How long have they been doing the procedure?
When will you get the results of the PGD?
What will happen if all the embryos are genetically abnormal?
What the clinic’s success rate is for frozen embryo transfer following embryo biopsy?


#7

Every failure is heartbreaking, If you’re not pregnant, you’ll stop taking progesterone and likely get your period within a week. If you don’t get your period or you have unusual bleeding, contact your doctor. If you’re interested in attempting another cycle of IVF, your doctor might suggest steps you can take to improve your chances of getting pregnant through IVF.Talk with your doctor about any factors that apply to you and how they may affect your chances of a successful pregnancy.


#8

This is my story. Me 40; DH 45. DX - PCOS, endo, one ovary and tube; MFI. Oct 2008: Mike is here! 7lbs 14oz, 20.75 inches; C-Section.
TTC #2 since Sept 2015. BFN= 3 IVFs. IVF#4 – early mc @6w4d, June 2018. Last IVF #5 (5dt of two 2AA blasts) – BFP!!
Beta #1, 11dp5dt= 295.
Beta #2, 13dp5dt= 825 (doubling time of 32 hours!); progesterone 130.
Last time we were using donor eggs at Ukrainian clinic bio texcom. Quite far away from home. But the clinic was doing its best to make our stay with them comfortable and the most effective.
Unless you feel good about using your repro center, do follow all dr’s recommendations! He does know your case the best!


#9

This is a tough journey. I hadn’t posted since my last BFN with the previous clinic. its was hard time to think what went wrong …having transferred grade A+ embryo…So I researched a lot when going through my last cycle …trying to think what was ''so wrong ‘’ this time that couldn’t work …After some research and advice I went to the fertility expert and booked appointment with nurse to repeat all blood tests… TSH, LH, PROLACTIN, THYROID , TESTOSTERONE and that time I asked for extra test clotting disorder . Last time all this tests I had done were all good …so I hoped they stay like that… After my BFN I had a period very heavy for like 11 days. now and again I had “milk” coming out and I experienced headache almost every day. I know my body went through long cycle and need time to come back to normal. I needed to heal emotionally before proceeding to treatments with our new Biotex clinic faraway from home. One thing is important – always keep on moving. Some day the BFN will fade when you get your baby in your arms.


#10

For me the worst though was doing injectibles. So here are some tips to ease the pain of the dreaded progesterone injections. First, warm the progesterone either to a comfortable room temperature or body temperature. You can also prepare the site of the injection using ledocaine but it requires a doc’s prescription.
Then this is good to learn to relax muscles. If you have help, lie flat on your stomach, with toes inward. Another method is to stand up against a table or other support, with your leg bent, relaxing the muscle, while someone else gives you the injection.
Then the injection itself. Keep the dry skin tight and smooth. Try to insert the needle into the skin quickly. After injection’s done massage its site. After about 30-60 seconds apply hot water bottle and continue massaging area. Also keep warm compress further.
I think I’ve written this because I feel like you’ll do it all again with the next shot IVF. So probably those tips might make you feel a bit more comfy with at least stimulation phase…
I believe we are all waiting for the updates. How are you doing, honey?


#11

A good doctor will not order a bunch of expensive tests after each IVF failure and doctor will make sure that his patients have realistic expectation about the entire IVF process. If you want to be a mature IVF patient, educate yourself about the process. This will help you to have sensible expectations of IVF treatment. It will protect you from an emotional breakdown; and from unnecessary tests and treatments.
Also I’ve recently read an article about a completely unique method for infertility treatment. It’s called the mitochondria replacement therapy. Here are some of the points:

  • It offers patients who are above 40 and for those, who suffer from low levels of AMH, an innovative program that makes it possible to get pregnant with their own eggs. This program gives women, who underwent numerous unsuccessful IVF cycles, aged 40+, patients with low mitochondrial functional activity, an excellent chance to give birth to a child who shares a genetic relationship with her and her partner.
    -To carry out such a procedure, an egg donor with a high functional activity of mitochondria, a patient, and sperm for IVF are required. Healthy functionally active mitochondria are taken from a donor’s oocyte and integrated with the patient’s cells. Next, fertilization with sperm and transfer of a healthy embryo into the patient’s uterus is performed. Mitochondria donation is a unique assistive reproductive technology, which is basically the implantation of a healthy and functionally active donor mitochondria into the cells of an infertile patient, that provides the patient’s cell with the necessary energy and contributes to successful pregnancy.
    -Mitochondrial DNA and Human DNA are different things. It only gives that necessary energy to the oocyst and helps with developing an embryo and make it stronger. DNA is in the core of the mitochondria, which are not used for donation. Therefore, genetically, mitochondria have no effect on the embryo. I hope everyone makes her best decision. Babydust to all!

#12

The chances of giving birth to a healthy baby after using IVF depend on various factors, including: The younger you are, the more likely you are to get pregnant and give birth to a healthy baby using your own eggs during IVF. Women age 41 and older are often counseled to consider using donor eggs during IVF to increase the chances of success. Embryo status - Transfer of embryos that are more developed is associated with higher pregnancy rates compared with less developed embryos (day two or three). However, not all embryos survive the development process. Talk with your doctor or other care provider about your specific situation.
Reproductive history.- Women who’ve previously given birth are more likely to be able to get pregnant using IVF than are women who’ve never given birth. Success rates are lower for women who’ve previously used IVF multiple times but didn’t get pregnant.
Cause of infertility. Having a normal supply of eggs increases your chances of being able to get pregnant using IVF. Women who have severe endometriosis are less likely to be able to get pregnant using IVF than are women who have unexplained infertility.
Lifestyle factors - Women who smoke typically have fewer eggs retrieved during IVF and may miscarry more often. Smoking can lower a woman’s chance of success using IVF by 50 percent. Obesity can decrease your chances of getting pregnant and having a baby. Use of alcohol, recreational drugs, excessive caffeine and certain medications also can be harmful.
Talk with your doctor about any factors that apply to you and how they may affect your chances of a successful pregnancy.


#13

Please do look onto https://biotexcom.com/a-unique-method-to-get-pregnant-in-your-40s-with-your-own-eggs/. It says, ‘‘BioTexCom offers patients who are above 40 and for those, who suffer from low levels of AMH, an innovative program that makes it possible to get pregnant with their own eggs. Mitochondria replacement therapy is an innovation and a breakthrough in the field of ART and the fertility treatment. This program gives women, who underwent numerous unsuccessful IVF cycles, aged 40+, patients with low mitochondrial functional activity, an excellent chance to give birth to a child who shares a genetic relationship with her and her partner. Mitochondrion is one of the most important components of any living cell, including the egg. In simple words, mitochondrion is the cell’s energy station. Essentially, its work consists in supplying the cell with vital energy for its normal functioning. Women that went through multiple unsuccessful IVF attempts, as well as of older reproductive age, need to restore oocyte mitochondria in order to successfully become pregnant. A woman can become pregnant only if there are functionally active mitochondria in her oocytes. Donation of mitochondria will allow thousands of hopeless women to give birth to a healthy child through IVF using mitochondrial donation. To carry out such a procedure, an egg donor with a high functional activity of mitochondria, a patient, and sperm for in vitro fertilization are required. Healthy functionally active mitochondria are taken from a donor’s oocyte and integrated with the patient’s cells. Next, fertilization with sperm and transfer of a healthy embryo into the patient’s uterus is performed. Mitochondria donation is a unique assistive reproductive technology, which is basically the implantation of a healthy and functionally active donor mitochondria into the cells of an infertile patient, that provides the patient’s cell with the necessary energy and contributes to successful pregnancy.’’ The point is that Mitochondrial DNA and Human DNA are different things. It only gives that necessary energy to the oocyst and helps with developing an embryo and make it stronger. DNA is in the core of the mitochondria, which are not used for donation. Therefore, genetically, mitochondria have no effect on the embryo.
I hope this helps to get even more ideas on how to make the following IVF shot successful.
All the very best xoxo


#14

Sometimes it does help avoiding sites for some time. The same thing for me. Being 40 years young with endo and PCOS and 2 failed fresh OE ivf cycles behind…felt too exhausted to even talk to people… This time we headed off for egg dontation route. A completely new thing for us - excited and nervous at the same time.They say, endometrial scratching doubles the success of implantation. The theory behind the procedure is that the scratches inside the womb prompt a repair reaction. It stimulates loads of useful growth factors, which in turn gives the embryo a better chance of implanting. Different doctors have different views on various elements of the procedure. For ex, when it’s done or how and where in the uterus the scratches should occur. But this does work to lot of women. I also had severe OHSS in my first cycle. Had 63 follicles and out of that they only got 7 eggs to ivf. The majority were too small or immature enough. Out of those 7 only 3 made it to day 5. We transferred 2, but got bfn. When they tested the fetus it was terribly abnormal. Since then I’ve had smaller egg hauls result in better quality eggs. Honestly I think it does have some effect…


#15

I did some research previously. It’s critically important to get enough folic acid. Folic acid helps prevent neural tube defects – serious birth defects of the spinal cord and the brain. It affects about 3,000 pregnancies a year in the US. Neural tube defects occur at a very early stage of development, before many women even know they’re pregnant – which is why it’s important to begin taking folic acid before you start trying to conceive.Some research suggests that folic acid may help lower your baby’s risk of other defects as well, such as cleft lip, cleft palate, and certain types of heart defects. It may also reduce your risk of preeclampsia, a serious blood pressure disorder that affects about 5 percent of pregnant women. Your body needs this nutrient to make normal red blood cells and prevent a type of anemia. It’s also essential for the production, repair, and functioning of DNA, our genetic map and a basic building block of cells. Getting enough folic acid is particularly important for the rapid cell growth of the placenta and a developing baby.


#16

After doing some research here are the things to share. ~ There are 3 basic reasons why IVF fails.The first is that embryo(s) transferred to the uterus was/were “incompetent”. In most cases, this is due to an irregular number of chromosomes in the embryo . In the remainder, it is due to genetic or molecular embryo abnormalities.
The second reason is an underlying implantation dysfunction that prevents the embryo from properly attaching to the uterine lining. The commonest causes for this include:
A thin endometrium (measuring less than 9 mm) at the peak of estradiol stimulation.
Surface lesions that protrude into the uterine cavity scarring, polyps and uterine fibroids that create a local adverse environment that prevents implantation.
Immunologic dysfunction that results in implantation failure.
The third reason relates to technical difficulty in the performance of embryo transfer , which is a rate limiting factor. It is an undeniable fact that not all RE’s are equally skilled at the performance of this important step of the IVF process unfortunately.
Hope you already know what to do next. Wishing you the best xx


#17

This is no one’s fault anyway. Noone can just expect infertility into their life flow. Moreover noone has right to judge or blame us for not being able to bring babies into this world. We aren’t the ones who did numerous abortions and then just thought ‘why not to have a little one?’ We struggle hard and get mad with this struggle. We endure so many things others have no idea of. My heart is with you, take care x