[quote=Miracle#1]For my first 2 transfers, I did Progesterone in oil(PIO) and both were BFN. I am wondering if there can be such a thing as too much progesterone for implantation.I am doing progesterone suppositories and hcg shots this cycle. Don’t know if this is enough or should I add in PIO? So confusing.
Anyone have any thoughts on this?[/quote]
I don’t know any doctor who thinks so. Most often, there is only a lower threshold, usually 15 or 20 ng/ml, sometimes 10 ng/ml. I’ve never seen a protocol with an upper limit. Some patients have very high progesterone levels because of follicular production, well above 100 ng/ml, and we temporarily discontinue their progesterone because they don’t need to use their supplements at that time, but not because we believe it would harm their pregnancy.
Low progesterone is a problem. One report suggested pregnancies should be kept above 6.5 ng/ml.