Causes of infertility


#24

IVF is a highly sophisticated and meticulously timed procedure. It involves removing a ripened egg or eggs from the female’s ovary. Fertilizing it with semen. Incubating the dividing cells in a laboratory dish. Finally, replacing the developing embryo in the uterus at the appropriate time.
The success and availability of IVF has raised the hopes of many infertile couples (Who have not been able to conceive because of infertility associated with not only blocked or absent fallopian tubes but also male infertility and many other causes!)
Time ago I was diagnosed on pcos & blocked fallopian tubes. AMH test results came in lest then 3,2. Tried accupuncture along with IVF shots but got no actual results. IVF#1 9/15 & IVF#2 12/15- both failed. Our dr suggested pgd as suspected me to be the carrier of a very rare disease. Another shot brought no luck. We both took a really long break for emotional recovery. Once a friend of mine went for surrogacy in Ukraine. She shared her positive experience with the clinic. We thought we could give it another try, using donor egg. It took us 2 shots DE IVF to conceive our adorable daughter. Whatever the reason for infertility is, DON’T GIVE UP!! There are plenty of options nowadays which can help!


#25

So what we expected to see during our first visit to the clinic… Sth like the typical clinic’s waiting room to keep us for some time before the main event. One of those afterthought, like everywhere… A daytime TV and a magazine stand – things which don’t make the clinic stand out. But we were amazed to see they made visiting the office a completely different experience instead of a chore! They created a special relationship with the patients, increased their satisfaction with details. The theme of care ran through everything they did at Biotexcom. Every member of their team seemed to feel honoured to have the opportunity to help change people’s lives! I believe it all comes down to their core value. Needs of the patient come first!! Their staff is respectful. If you spend a day there and you grab anybody and ask them what’s the purpose of your work, they would more likely to say ‘to help build families’. Absolutely love their approach :wink:


#26

Found this, thought it might be of some interest. ~The first and most common type of PCOS is transferred through a woman’s genetic makeup and is usually characterized by a woman’s high LH levels. LH level is generally at a much higher count than the FSH in a woman with this type of PCOS. Generally speaking a typical FSH level will be higher than the LH levels, these measurements are taken by a specialist through a blood sample. Often this type of PCOS is associated with a higher male hormone concentration, and often associated with insulin resistance.
The second most common type of PCOS is adrenal. In the case of it, a male hormone is overactive rather than a female hormone. In many cases the reason an adrenal imbalance of male hormones has occurred is because of long term stress. stress hormone has ultimately produced so much cortisol that the body starts to prioritize resources elsewhere besides the reproductive area!!
In the third type in the patient there is more than one ovarian cyst that has been engorged for a long period of time, resulting in size and shape permanence of the cysts. This type of PCOS is common with severe diagnoses of endometriosis, any form of extensive surgery in the pelvic region, and chronic pelvic inflammatory disease. Women do not respond to fertility drugs with overactive or hyperstimulation but instead are considered to be poor responders to the drugs.


#27

Having PCOS varies from woman to woman, here are symptoms that could indicate you have PCOS. If you feel any of these symptoms are effecting you then talk to you doctor! Not every woman with PCOS will have every symptom, and you do not have to have cysts on your ovaries to have PCOS.
Symptoms of PCOS:
Reduced menstrual cycles than normal or complete lack of having any cycles.
Some can have monthly cycles but not actually be ovulating.
Heavy bleeding during your period, and spotting in between cycles.
Hair loss on your scalp
Excess hair growth on your body such as your face, chest, back, stomach, thumbs, or toes.
Acne and oily skin
Weight gain that is mostly gained around your midsection.
Miscarriage and infertility
Insulin resistance. This can cause miscarriage, poor egg quality, and irregular periods.
Cysts on your ovaries
Difficulty to lose weight despite dieting and exercise
Multiple positive OPKs throughout your cycle, but no ovulation happens.


#28

Our Dr at Biotex says there is no one single test that is done to diagnose PCOS. It is more a combination of different test results and your symptoms that will lead to a diagnoses.
Common testing that is done to diagnose PCOS:
Blood tests for LH, FSH, TSH, Testosterone, Prolactin, Cholesterol, Triglycerides, Vitamin D.
Progesterone blood test on 7 days past ovulating.
Glucose tolerance test, and fasting Blood glucose numbers to check for insulin resistance.
A pelvic ultasound to check your ovaries for cysts, and to see if they are enlarged.


#29

I’m going to add as for the treatments for uterine issues. Those include: Fibroids – surgery can be considered. Polyps - surgery can be considered. Adenomyosis no treatment required. Endometriosis could be surgery in form of laparoscopy or ultra long IVF protocol. Intrauterine adhesions – surgery. Abnormal uterine shape - possible surgery. Difficult cervix affecting embryo transfer – ultrasound guided transfer and hysteroscopy and dilatation of the cervix. Early rise in progesterone prior to egg collection in an IVF cycle – freezing of embryos prior to transfer to use later in a frozen cycle.
Then things considering general maternal and paternal health.


#30

The average IVF success rate globally is under 50 percent. This means that almost half the people have unsuccessful IVF cycles and unfortunately. Moreover there is no scientific way to determine the exact reason for failure of IVF. IVF is an expensive procedure with no guarantee of success. Once you get your head around the IVF cost the most important concern for patients is to know about their chances of success. The IVF clinic you choose, lab factors, the method of performing the procedure, the competence of the embryologist are all factors that can affect your IVF results but over 50 percent of IVF cases will fail. Even if these conditions are perfect. If even after choosing the right IVF clinic, you are wondering why it didn’t work for you, try to get an idea of personal factors that could be causing problem. Like most biological processes, pregnancy and the development of an embryo inside the human womb is a complex procedure. What we do not know about pregnancy is much greater than what we do know. Some specific factors that may be to blame. One way to improve your chances of IVF success is to opt for PGS testing to study the genetic content of embryos. before transferring them to the uterus. This allows the doctor to select the embryos with most chances of success. Embryo implantation rates are also higher in women near the age of 35.


#31

Before an IVF cycle, medications are given to get the ovaries to produce more eggs. If you already have a reduced number of eggs or have elevated FSH levels, your body might not respond properly to IVF medications, which is not a good sign. The sperm and eggs both have specific receptors on their surface that allow for their interaction. However, barring chromosomal factors, sperm are usually not the among the reasons for failure of IVF. Because any quantitative or qualitative problems with the sperm are easily detected during semen analysis. In this case the patients are given the option of ICSI or IVF with donor sperm. The rate of chromosomal abnormalities in human embryos is one of the major factors for IVF failure though. Various studies have shown that the rate of chromosomal abnormalities in human eggs start to increase after the mid 30s.
In most cases, where the uterus is free of any obvious problems, switching to DE IVF is more likely to bring you success. If your eggs are responsible for the problem - Even transferring them to a surrogate’s uterus will produce the same result. IVF failure in older women is mostly caused due to older eggs which are not viable for pregnancy. The point is to find the best fertility center with professional staff to be treated at. Only there you’ll be advised the best on your further treatment steps.


#32

If anyone is interested, you can visit the link - http://worldcenterofbaby.com. It is the website of my agency that I have chosen a few months ago. There is a lot of clinics i Ukraine that offer similar services, but I am somehow certain that we have made the best choice out of all. #makeitfamous


#33

When to seek help sometimes depends on your age:
Up to age 35, most doctors recommend trying to get pregnant for at least a year before testing or treatment.
If you’re between 35 and 40, discuss your concerns with your doctor after six months of trying.
If you’re older than 40, your doctor may want to begin testing or treatment right away.
Your doctor may also want to begin testing or treatment right away if you or your partner has known fertility problems, or if you have a history of irregular or painful periods, pelvic inflammatory disease, repeated miscarriages, prior cancer treatment, or endometriosis.
Each of these factors is essential to become pregnant:
You need to ovulate. To get pregnant, your ovaries must produce and release an egg, a process known as ovulation. Your doctor can help evaluate your menstrual cycles and confirm ovulation.
Your partner needs sperm. For most couples, this isn’t a problem unless your partner has a history of illness or surgery. Your doctor can run some simple tests to evaluate the health of your partner’s sperm.
You need to have regular intercourse. You need to have regular sexual intercourse during your fertile time. Your doctor can help you better understand when you’re most fertile.
You need to have open fallopian tubes and a normal uterus. The egg and sperm meet in the fallopian tubes, and the embryo needs a healthy uterus in which to grow.
For pregnancy to occur, every step of the human reproduction process has to happen correctly. The steps in this process are:
One of the two ovaries releases a mature egg.
The egg is picked up by the fallopian tube.
Sperm swim up the cervix, through the uterus and into the fallopian tube to reach the egg for fertilization.
The fertilized egg travels down the fallopian tube to the uterus.
The fertilized egg implants and grows in the uterus.
In women, a number of factors can disrupt this process at any step. Female infertility is caused by one or more of the factors below.


#34

Ovulation disorders. Meaning you ovulate infrequently or not at all, account for infertility in about 1 in 4 infertile couples. Problems with the regulation of reproductive hormones by the hypothalamus or the pituitary gland, or problems in the ovary, can cause ovulation disorders.
PCOS causes a hormone imbalance, which affects ovulation. PCOS is associated with insulin resistance and obesity, abnormal hair growth on the face or body, and acne. It’s the most common cause of female infertility.
Hypothalamic dysfunction. Two hormones produced by the pituitary gland are responsible for stimulating ovulation each month - (FSH) and luteinizing hormone (LH). Excess physical or emotional stress, a very high or very low body weight, or a recent substantial weight gain or loss can disrupt production of these hormones and affect ovulation. Irregular or absent periods are the most common signs.
Premature ovarian failure. Also called primary ovarian insufficiency, this disorder is usually caused by an autoimmune response or by premature loss of eggs from your ovary (possibly from genetics or chemotherapy). The ovary no longer produces eggs, and it lowers estrogen production in women under the age of 40.
Too much prolactin. The pituitary gland may cause excess production of prolactin (hyperprolactinemia), which reduces estrogen production and may cause infertility. Usually related to a pituitary gland problem, this can also be caused by medications you’re taking for another disease.
Damage to fallopian tubes (tubal infertility). Damaged or blocked fallopian tubes keep sperm from getting to the egg or block the passage of the fertilized egg into the uterus. Causes of fallopian tube damage or blockage can include:
Pelvic inflammatory disease, an infection of the uterus and fallopian tubes due to chlamydia, gonorrhea or other sexually transmitted infections
Previous surgery in the abdomen or pelvis, including surgery for ectopic pregnancy, in which a fertilized egg implants and develops in a fallopian tube instead of the uterus
Pelvic tuberculosis, a major cause of tubal infertility worldwide.
Endometriosis occurs when tissue that normally grows in the uterus implants and grows in other locations. This extra tissue growth - and the surgical removal of it - can cause scarring, which may block fallopian tubes and keep an egg and sperm from uniting.
Endometriosis can also affect the lining of the uterus, disrupting implantation of the fertilized egg. The condition also seems to affect fertility in less-direct ways, such as damage to the sperm or egg.
Uterine or cervical causes. Several uterine or cervical causes can impact fertility by interfering with implantation or increasing the likelihood of a miscarriage:
Benign polyps or tumors (fibroids or myomas) are common in the uterus. Some can block fallopian tubes or interfere with implantation, affecting fertility. However, many women who have fibroids or polyps do become pregnant.
Endometriosis scarring or inflammation within the uterus can disrupt implantation.
Uterine abnormalities present from birth, such as an abnormally shaped uterus, can cause problems becoming or remaining pregnant.
Cervical stenosis, a narrowing of the cervix, can be caused by an inherited malformation or damage to the cervix.
Sometimes the cervix can’t produce the best type of mucus to allow the sperm to travel through the cervix into the uterus.
Unexplained infertility. Sometimes, the cause of infertility is never found. A combination of several minor factors in both partners could cause unexplained fertility problems. Although it’s frustrating to get no specific answer, this problem may correct itself with time. But, you shouldn’t delay treatment for infertility.


#35

Hey millie thanks for the useful information u gave .


#36

Seems I’ve already answered one of your posts, saying I got to know a lot about tubes blockage through Bio tex com youtube videos. As I’ve mentioned, Fallopian tubes can be damaged in many different ways. If the furthest end of the tube is blocked, then the tube cannot pick up an ovulated egg. This may also cause the tube to collect fluid and dilate, creating what is known as a hydrosalpinx. It is important to know if your blocked tubes created a hydrosalpinx, because the fluid that collects inside can decrease your chance of successful pregnancy with IVF by about 50%. If your doctor finds a hydrosalpinx, they may recommend that you have the tube removed or blocked using a surgical procedure, so that the fluid from the hydrosalpinx does not communicate with the uterus. Damaged fallopian tubes may sometimes be partially open. This can increase your risk of an ectopic pregnancy, or a pregnancy that implants outside the uterus. The fallopian tube is the most common place for an ectopic pregnancy to grow. An ectopic pregnancies can be dangerous if it grows large enough to cause heavy bleeding, and so in almost all cases it should be removed using surgery or medication.
The good news though is that blocked fallopian tubes prevent natural conception, but IVF can bypass the tubes. During IVF, the ovaries are stimulated to produce several eggs. The eggs are then retrieved using a short procedure under anesthesia. They are then fertilized in the laboratory. Created embryos are placed into the uterus through the cervix. so the fallopian tubes are bypassed all together.
Besides, I’ve shared the info on the innovative method the clinic offers these days. It’s called the mitochondrial donation. This method allows the patients who are above 40 and for those, who suffer from low levels of AMH, to conceive with their own eggs. How is this possible? - To carry out such a procedure, an egg donor with a high functional activity of mitochondria (a blastocyst production rate of 70% or more), a patient (willing to get pregnant), and sperm for in vitro fertilization are required. Healthy functionally active mitochondria are taken from a donor’s oocyte and integrated with the patient’s cells. Next, fertilization with sperm and transfer of a healthy embryo into the patient’s uterus is performed. Basically it’s the implantation of a healthy and functionally active donor mitochondria into the cells of an infertile patient, that provides the patient’s cell with the necessary energy and contributes to successful pregnancy.
Isn’t it amazing?! You use donor’s mitochondria only, which doesn’t affect the baby’s DNA at all. You use own egg with a new ‘‘power station’’. So the future baby’s completely YOURS!!


#37

Firstly, male fertility issues.
Male fertility requires that the testicles produce enough healthy sperm, and that the sperm is ejaculated effectively into the woman’s vagina and travels to the egg. Tests for male infertility attempt to determine whether any of these processes are impaired. You may have a general physical exam, including examination of your genitals. Specific fertility tests may include:
Semen analysis. Your doctor may ask for one or more semen specimens. Semen is generally obtained by masturbating or by interrupting intercourse and ejaculating your semen into a clean container. A lab analyzes your semen specimen. In some cases, sperm may be tested for in the urine.
Hormone testing. You may have a blood test to determine the level of testosterone and other male hormones.
Genetic testing. Genetic testing may be done to determine whether there’s a genetic defect causing infertility.
Testicular biopsy. In select cases, a testicular biopsy may be performed to identify abnormalities contributing to infertility and to retrieve sperm to use with assisted reproductive techniques, such as IVF.
Imaging. In certain situations, imaging studies such as a brain MRI, bone mineral density scan, transrectal or scrotal ultrasound, or a test of the vas deferens (vasography) may be performed.
Other specialty testing. In rare cases, other tests to evaluate the quality of the sperm may be performed, such as evaluating a semen specimen for DNA abnormalities.


#38

Secondly, fertility issues in women. Fertility for women relies on the ovaries releasing healthy eggs. Her reproductive tract must allow an egg to pass into her fallopian tubes and join with sperm for fertilization. The fertilized egg must travel to the uterus and implant in the lining. Tests for female infertility attempt to determine whether any of these processes are impaired. You may have a general physical exam, including a regular gynecological exam. Specific fertility tests may include:
Ovulation testing. A blood test measures hormone levels to determine whether you’re ovulating.
Hysterosalpingography evaluates the condition of your uterus and fallopian tubes and looks for blockages or other problems. X-ray contrast is injected into your uterus, and an X-ray is taken to determine if the cavity is normal and ensure the fluid spills out of your fallopian tubes.
Ovarian reserve testing. This testing helps determine the quality and quantity of the eggs available for ovulation. This approach often begins with hormone testing early in the menstrual cycle.
Other hormone tests check levels of ovulatory hormones, as well as pituitary hormones that control reproductive processes.
Imaging tests. Pelvic ultrasound looks for uterine or fallopian tube disease. Sometimes a hysterosonography is used to see details inside the uterus that are not seen on a regular ultrasound. Depending on your situation, rarely your testing may include:
Hysteroscopy. Based on your symptoms, your doctor may request a hysteroscopy to look for uterine or fallopian tube disease. During hysteroscopy, your doctor inserts a thin, lighted device through your cervix into your uterus to view any potential abnormalities.
Laparoscopy. This minimally invasive surgery involves making a small incision beneath your navel and inserting a thin viewing device to examine your fallopian tubes, ovaries and uterus. A laparoscopy may identify endometriosis, scarring, blockages or irregularities of the fallopian tubes, and problems with the ovaries and uterus.
Genetic testing. Genetic testing helps determine whether there’s a genetic defect causing infertility.
REMEMBER! Not everyone needs to have all, or even many, of these tests before the cause of infertility is found. You and your doctor will decide which tests you will have and when.


#39

Thank you for sharing the information.


#40

I should add this. You’ll also face the possibility of psychological challenges no matter your results:
Not achieving pregnancy, or having a miscarriage - The emotional stress of not being able to have a baby can be devastating even on the most loving and affectionate relationships.
Success - Even if fertility treatment is successful, it’s common to experience stress and fear of failure during pregnancy. If you have a history of depression or anxiety disorder, you’re at increased risk of these problems recurring in the months after your child’s birth.
Multiple births.- A successful pregnancy that results in multiple births introduces medical complexities and the likelihood of significant emotional stress both during pregnancy and after delivery.
Do seek professional help if the emotional impact of the outcome of your fertility treatments becomes too heavy for you or your partner.


#41

My husband (46 years old) and I (41 years old) have faced infertility diagnosis for 6 long years. The main reason of my pregnancy failure was that my egg cells couldn’t mature, so I didn’t have ovulation. We consulted lots of experts, took different treatments but nothing helped. We were too exhausted to continue the useless procedures. With our problem we went abroad. Only in biotexcom they provided diagnostics and procedures met our requirements and expectations to the full. That was a great success. As you understand, I couldn’t produce healthy mature eggs. So, we were in need of egg donation as well. The eggs were taken from the most attractive donor (due to our profile requirements) and fertilized with my husband’s sperm. The main pro is that the clinic works with blastocyst (that is implanting the embryos in the woman’s uterus yet on the fifth day) We appreciated the work of the staff. The people we met were very kind and understanding. I could share all my troubles with them. You see, support is very important when you face such problems! (


#42

Sometimes, IVF is offered as a primary treatment for infertility in women over age 40. IVF can also be done if you have certain health conditions. For example, IVF may be an option if you or your partner has:
Fallopian tube damage or blockage makes it difficult for an egg to be fertilized or for an embryo to travel to the uterus.
If ovulation is infrequent or absent, fewer eggs are available for fertilization.
Premature ovarian failure is the loss of normal ovarian function before age 40. If your ovaries fail, they don’t produce normal amounts of the hormone estrogen or have eggs to release regularly.
Endometriosis occurs when the uterine tissue implants and grows outside of the uterus. Often affecting the function of the ovaries, uterus and fallopian tubes.
Fibroids are benign tumors in the wall of the uterus and are common in women in their 30s and 40s. Fibroids can interfere with implantation of the fertilized egg.
If you’ve had tubal ligation and want to conceive, IVF may be an alternative to tubal ligation reversal.
Below-average sperm concentration, weak movement of sperm (poor mobility), or abnormalities in sperm size and shape can make it difficult for sperm to fertilize an egg. If semen abnormalities are found, your partner might need to see a specialist to determine if there are correctable problems or underlying health concerns.
Unexplained infertility means no cause of infertility has been found despite evaluation for common causes.
If you or your partner is at risk of passing on a genetic disorder to your child, you may be candidates for preimplantation genetic diagnosis. After the eggs are harvested and fertilized, they’re screened for certain genetic problems, although not all genetic problems can be found. Embryos that don’t contain identified problems can be transferred to the uterus.
Fertility preservation for cancer or other health conditions. If you’re about to start cancer treatment that could harm your fertility, IVF for fertility preservation may be an option. Women can have eggs harvested from their ovaries and frozen in an unfertilized state for later use. Or the eggs can be fertilized and frozen as embryos for future use.
Women who don’t have a functional uterus or for whom pregnancy poses a serious health risk might choose IVF using another person to carry the pregnancy (gestational carrier). In this case, the woman’s eggs are fertilized with sperm, but the resulting embryos are placed in the gestational carrier’s uterus.
To be honest, sometimes I felt alone in my feelings and now traumatized and exceptionally frightened of all things medical/injections I felt. I did feel hope when I started cycling and treatments but it immediately upended my entire life - stopping working, commuting to a clinic, remortgaging a house, facing my fear of surgery, procedures, and injections. To be honest I felt horrified at the massive hole this sent me down, and could only compare it to my friends and siblings all having babies instantly, no problem, each time, so happy and celebratory, and no aspect of their lives sacrificed. The shock of infertility and what it took felt so magnified and sad. I felt such a loss of my “former” life in every way…
Thanks God it’s all just a note from my past now.


#43

At the same time, having had talked about the IVF benefits, I should admit it’s not without risks. I think just like any other med invasion…So be aware of the following steps of IVF treatment which may carry risks:
IVF increases the risk of multiple births if more than one embryo is implanted in your uterus. A pregnancy with multiple fetuses carries a higher risk of early labor and low birth weight than pregnancy with a single fetus does.
Premature delivery and low birth weight. Research suggests that use of IVF slightly increases the risk that a baby will be born early or with a low birth weight.
Use of injectable fertility drugs, such as human chorionic gonadotropin (HCG), to induce ovulation can cause ovarian hyperstimulation syndrome, in which your ovaries become swollen and painful. Signs and symptoms typically last a week and include mild abdominal pain, bloating, nausea, vomiting and diarrhea. If you become pregnant, however, your symptoms might last several weeks. Rarely, it’s possible to develop a more-severe form of ovarian hyperstimulation syndrome that can also cause rapid weight gain and shortness of breath.
The rate of miscarriage for women who conceive using IVF with fresh embryos is similar to that of women who conceive naturally but the rate increases with maternal age. Use of frozen embryos during IVF, however, may slightly increase the risk of miscarriage.
Use of an aspirating needle to collect eggs could possibly cause bleeding, infection or damage to the bowel, bladder or a blood vessel. Risks are also associated with general anesthesia, if used.
About 2 to 5 percent of women who use IVF will have an ectopic pregnancy. And the fertilized egg can’t survive outside the uterus, and there’s no way to continue the pregnancy.
The age of the mother is the primary risk factor in the development of birth defects, no matter how the child is conceived. More research is needed to determine whether babies conceived using IVF might be at increased risk of certain birth defects. Some experts believe that the use of IVF does not increase the risk of having a baby with birth defects.
Although some early studies suggested there may be a link between certain medications used to stimulate egg growth and the development of a specific type of ovarian tumor, more recent studies do not support these findings.
Use of IVF can be financially, physically and emotionally draining. Support from counselors, family and friends can help you and your partner through the ups and downs of infertility treatment.
That’s why when choosing an in vitro fertilization (IVF) clinic, keep in mind that a clinic’s success rate depends on many factors, such as patients’ ages and medical issues, as well as the clinic’s treatment population and treatment approaches. Ask for detailed information about the costs associated with each step of the procedure. IVF is a treatment for infertility or genetic problems. If IVF is performed to treat infertility, you and your partner might be able to try less invasive treatment options before attempting IVF, including fertility drugs to increase production of eggs or intrauterine insemination.