Causes of infertility


#22

hey there! I hope you are doing great. there are alot of causes for infertility. women are accountable for 20% of infertility and 20% men and the 60% other reasons. reasons like external environmental factors. PCOS is a big reason , having blocked tubes etc. for women and couples like this , there is an option for surrogacy and IVF. surrogacy is a great option for women struggling with infertility.


#23

Congrats with your surrogacy success!! May all of you be healthy and happy in your new family!!
I’ve shared this on another thread already. Thought I have to post here. I’ve got loads of things to share about surrogacy process in Ukaine. 'Cause we’ve been through treatments there and are currently back for a sibling!! So here we go I absolutely love the idea of coming for surrogacy to this very country. Firstly, because it’s surrogacy friendly law. The baby is considered to be yours from the moment of conception. The surrogate cannot stand any rights. She has no right to keep the baby after delivery which makes couples absolutely safe. The birth certificate is issues with the names of the intended parents, so the baby’s theirs. Eveything’s simple when being guided with professionals in this field. I know for sure our biotex helps the IP with obtaining the birth certificate and other legal services. Friends of mine had a trouble when being at the exit process. She had a single letter differed in their marriage certificate which caused them a huge trouble. But biotex helped them through and soon they could take their baby girl home. Surrogacy may be the blessing for many people. But in Ukraine surrogacy is allow for heterosexual married couples only.
surrogacy process goes on like this.
Initial consultation. It usually contains the following activities: A set of tests depending on the program (fasting is mandatory). Consultation with a fertility specialist who will be in charge of your program (in case of stimulation you will need to have the transvaginal ultrasound check done). Consultation with a manager who will guide you through the program step by step. Signing of contracts. Before any initial consultation you will receive the Guidelines for the Initial Consultation – failure to follow these recommendations may affect the initial consultation in a negative way.
Search & confirmation of a surrogate mother, matching process. Waiting time depends on the type of contact.
Stimulation & synchronisation stage (about 2 weeks). The cycle of egg donor or the biological mother is synchronised with the cycle of a surrogate mother. According to your contract you have to follow all doctors instruction. In case of self-treatment or violation of the treatment protocol, the clinic may cancel the cycle and terminate the contract.
Fertilization day, embryo transfer - the 2nd visit. In case the biological mother undergoes hormonal stimulation and is being prepared for egg retrieval, the second visit may take up to 10 days. If we are talking about surrogacy using own eggs it is not recommended to leave the same day. Flying the following day is fine.The rules for sperm donation are similar as for the initial consultation – a man needs to abstain from ejaculation from 3 to 5 days before. After fertilisation the embryo development is monitored by embryology unit. The embryo transfer takes place on the 5th day. You will receive the protocol of embryo cultivation and transfer within 3 working days after the embryo transfer.
HCG test, pregnancy confirmation.
Pregnancy monitoring. Delivery.
Obtaining of the birth certificate for the baby (up to 1 week).
For more information you may visit http://oursurrogacyblog.wordpress.com/ or http://asiu.us/. People are telling their incredible stories about surrogacy at bio tex com.
Hope this helps those looking for more insight .


#24

IVF is a highly sophisticated and meticulously timed procedure. It involves removing a ripened egg or eggs from the female’s ovary. Fertilizing it with semen. Incubating the dividing cells in a laboratory dish. Finally, replacing the developing embryo in the uterus at the appropriate time.
The success and availability of IVF has raised the hopes of many infertile couples (Who have not been able to conceive because of infertility associated with not only blocked or absent fallopian tubes but also male infertility and many other causes!)
Time ago I was diagnosed on pcos & blocked fallopian tubes. AMH test results came in lest then 3,2. Tried accupuncture along with IVF shots but got no actual results. IVF#1 9/15 & IVF#2 12/15- both failed. Our dr suggested pgd as suspected me to be the carrier of a very rare disease. Another shot brought no luck. We both took a really long break for emotional recovery. Once a friend of mine went for surrogacy in Ukraine. She shared her positive experience with the clinic. We thought we could give it another try, using donor egg. It took us 2 shots DE IVF to conceive our adorable daughter. Whatever the reason for infertility is, DON’T GIVE UP!! There are plenty of options nowadays which can help!


#25

So what we expected to see during our first visit to the clinic… Sth like the typical clinic’s waiting room to keep us for some time before the main event. One of those afterthought, like everywhere… A daytime TV and a magazine stand – things which don’t make the clinic stand out. But we were amazed to see they made visiting the office a completely different experience instead of a chore! They created a special relationship with the patients, increased their satisfaction with details. The theme of care ran through everything they did at Biotexcom. Every member of their team seemed to feel honoured to have the opportunity to help change people’s lives! I believe it all comes down to their core value. Needs of the patient come first!! Their staff is respectful. If you spend a day there and you grab anybody and ask them what’s the purpose of your work, they would more likely to say ‘to help build families’. Absolutely love their approach :wink:


#26

Found this, thought it might be of some interest. ~The first and most common type of PCOS is transferred through a woman’s genetic makeup and is usually characterized by a woman’s high LH levels. LH level is generally at a much higher count than the FSH in a woman with this type of PCOS. Generally speaking a typical FSH level will be higher than the LH levels, these measurements are taken by a specialist through a blood sample. Often this type of PCOS is associated with a higher male hormone concentration, and often associated with insulin resistance.
The second most common type of PCOS is adrenal. In the case of it, a male hormone is overactive rather than a female hormone. In many cases the reason an adrenal imbalance of male hormones has occurred is because of long term stress. stress hormone has ultimately produced so much cortisol that the body starts to prioritize resources elsewhere besides the reproductive area!!
In the third type in the patient there is more than one ovarian cyst that has been engorged for a long period of time, resulting in size and shape permanence of the cysts. This type of PCOS is common with severe diagnoses of endometriosis, any form of extensive surgery in the pelvic region, and chronic pelvic inflammatory disease. Women do not respond to fertility drugs with overactive or hyperstimulation but instead are considered to be poor responders to the drugs.


#27

Having PCOS varies from woman to woman, here are symptoms that could indicate you have PCOS. If you feel any of these symptoms are effecting you then talk to you doctor! Not every woman with PCOS will have every symptom, and you do not have to have cysts on your ovaries to have PCOS.
Symptoms of PCOS:
Reduced menstrual cycles than normal or complete lack of having any cycles.
Some can have monthly cycles but not actually be ovulating.
Heavy bleeding during your period, and spotting in between cycles.
Hair loss on your scalp
Excess hair growth on your body such as your face, chest, back, stomach, thumbs, or toes.
Acne and oily skin
Weight gain that is mostly gained around your midsection.
Miscarriage and infertility
Insulin resistance. This can cause miscarriage, poor egg quality, and irregular periods.
Cysts on your ovaries
Difficulty to lose weight despite dieting and exercise
Multiple positive OPKs throughout your cycle, but no ovulation happens.


#28

Our Dr at Biotex says there is no one single test that is done to diagnose PCOS. It is more a combination of different test results and your symptoms that will lead to a diagnoses.
Common testing that is done to diagnose PCOS:
Blood tests for LH, FSH, TSH, Testosterone, Prolactin, Cholesterol, Triglycerides, Vitamin D.
Progesterone blood test on 7 days past ovulating.
Glucose tolerance test, and fasting Blood glucose numbers to check for insulin resistance.
A pelvic ultasound to check your ovaries for cysts, and to see if they are enlarged.


#29

I’m going to add as for the treatments for uterine issues. Those include: Fibroids – surgery can be considered. Polyps - surgery can be considered. Adenomyosis no treatment required. Endometriosis could be surgery in form of laparoscopy or ultra long IVF protocol. Intrauterine adhesions – surgery. Abnormal uterine shape - possible surgery. Difficult cervix affecting embryo transfer – ultrasound guided transfer and hysteroscopy and dilatation of the cervix. Early rise in progesterone prior to egg collection in an IVF cycle – freezing of embryos prior to transfer to use later in a frozen cycle.
Then things considering general maternal and paternal health.


#30

The average IVF success rate globally is under 50 percent. This means that almost half the people have unsuccessful IVF cycles and unfortunately. Moreover there is no scientific way to determine the exact reason for failure of IVF. IVF is an expensive procedure with no guarantee of success. Once you get your head around the IVF cost the most important concern for patients is to know about their chances of success. The IVF clinic you choose, lab factors, the method of performing the procedure, the competence of the embryologist are all factors that can affect your IVF results but over 50 percent of IVF cases will fail. Even if these conditions are perfect. If even after choosing the right IVF clinic, you are wondering why it didn’t work for you, try to get an idea of personal factors that could be causing problem. Like most biological processes, pregnancy and the development of an embryo inside the human womb is a complex procedure. What we do not know about pregnancy is much greater than what we do know. Some specific factors that may be to blame. One way to improve your chances of IVF success is to opt for PGS testing to study the genetic content of embryos. before transferring them to the uterus. This allows the doctor to select the embryos with most chances of success. Embryo implantation rates are also higher in women near the age of 35.


#31

Before an IVF cycle, medications are given to get the ovaries to produce more eggs. If you already have a reduced number of eggs or have elevated FSH levels, your body might not respond properly to IVF medications, which is not a good sign. The sperm and eggs both have specific receptors on their surface that allow for their interaction. However, barring chromosomal factors, sperm are usually not the among the reasons for failure of IVF. Because any quantitative or qualitative problems with the sperm are easily detected during semen analysis. In this case the patients are given the option of ICSI or IVF with donor sperm. The rate of chromosomal abnormalities in human embryos is one of the major factors for IVF failure though. Various studies have shown that the rate of chromosomal abnormalities in human eggs start to increase after the mid 30s.
In most cases, where the uterus is free of any obvious problems, switching to DE IVF is more likely to bring you success. If your eggs are responsible for the problem - Even transferring them to a surrogate’s uterus will produce the same result. IVF failure in older women is mostly caused due to older eggs which are not viable for pregnancy. The point is to find the best fertility center with professional staff to be treated at. Only there you’ll be advised the best on your further treatment steps.


#32

If anyone is interested, you can visit the link - http://worldcenterofbaby.com. It is the website of my agency that I have chosen a few months ago. There is a lot of clinics i Ukraine that offer similar services, but I am somehow certain that we have made the best choice out of all. #makeitfamous


#33

When to seek help sometimes depends on your age:
Up to age 35, most doctors recommend trying to get pregnant for at least a year before testing or treatment.
If you’re between 35 and 40, discuss your concerns with your doctor after six months of trying.
If you’re older than 40, your doctor may want to begin testing or treatment right away.
Your doctor may also want to begin testing or treatment right away if you or your partner has known fertility problems, or if you have a history of irregular or painful periods, pelvic inflammatory disease, repeated miscarriages, prior cancer treatment, or endometriosis.
Each of these factors is essential to become pregnant:
You need to ovulate. To get pregnant, your ovaries must produce and release an egg, a process known as ovulation. Your doctor can help evaluate your menstrual cycles and confirm ovulation.
Your partner needs sperm. For most couples, this isn’t a problem unless your partner has a history of illness or surgery. Your doctor can run some simple tests to evaluate the health of your partner’s sperm.
You need to have regular intercourse. You need to have regular sexual intercourse during your fertile time. Your doctor can help you better understand when you’re most fertile.
You need to have open fallopian tubes and a normal uterus. The egg and sperm meet in the fallopian tubes, and the embryo needs a healthy uterus in which to grow.
For pregnancy to occur, every step of the human reproduction process has to happen correctly. The steps in this process are:
One of the two ovaries releases a mature egg.
The egg is picked up by the fallopian tube.
Sperm swim up the cervix, through the uterus and into the fallopian tube to reach the egg for fertilization.
The fertilized egg travels down the fallopian tube to the uterus.
The fertilized egg implants and grows in the uterus.
In women, a number of factors can disrupt this process at any step. Female infertility is caused by one or more of the factors below.


#34

Ovulation disorders. Meaning you ovulate infrequently or not at all, account for infertility in about 1 in 4 infertile couples. Problems with the regulation of reproductive hormones by the hypothalamus or the pituitary gland, or problems in the ovary, can cause ovulation disorders.
PCOS causes a hormone imbalance, which affects ovulation. PCOS is associated with insulin resistance and obesity, abnormal hair growth on the face or body, and acne. It’s the most common cause of female infertility.
Hypothalamic dysfunction. Two hormones produced by the pituitary gland are responsible for stimulating ovulation each month - (FSH) and luteinizing hormone (LH). Excess physical or emotional stress, a very high or very low body weight, or a recent substantial weight gain or loss can disrupt production of these hormones and affect ovulation. Irregular or absent periods are the most common signs.
Premature ovarian failure. Also called primary ovarian insufficiency, this disorder is usually caused by an autoimmune response or by premature loss of eggs from your ovary (possibly from genetics or chemotherapy). The ovary no longer produces eggs, and it lowers estrogen production in women under the age of 40.
Too much prolactin. The pituitary gland may cause excess production of prolactin (hyperprolactinemia), which reduces estrogen production and may cause infertility. Usually related to a pituitary gland problem, this can also be caused by medications you’re taking for another disease.
Damage to fallopian tubes (tubal infertility). Damaged or blocked fallopian tubes keep sperm from getting to the egg or block the passage of the fertilized egg into the uterus. Causes of fallopian tube damage or blockage can include:
Pelvic inflammatory disease, an infection of the uterus and fallopian tubes due to chlamydia, gonorrhea or other sexually transmitted infections
Previous surgery in the abdomen or pelvis, including surgery for ectopic pregnancy, in which a fertilized egg implants and develops in a fallopian tube instead of the uterus
Pelvic tuberculosis, a major cause of tubal infertility worldwide.
Endometriosis occurs when tissue that normally grows in the uterus implants and grows in other locations. This extra tissue growth - and the surgical removal of it - can cause scarring, which may block fallopian tubes and keep an egg and sperm from uniting.
Endometriosis can also affect the lining of the uterus, disrupting implantation of the fertilized egg. The condition also seems to affect fertility in less-direct ways, such as damage to the sperm or egg.
Uterine or cervical causes. Several uterine or cervical causes can impact fertility by interfering with implantation or increasing the likelihood of a miscarriage:
Benign polyps or tumors (fibroids or myomas) are common in the uterus. Some can block fallopian tubes or interfere with implantation, affecting fertility. However, many women who have fibroids or polyps do become pregnant.
Endometriosis scarring or inflammation within the uterus can disrupt implantation.
Uterine abnormalities present from birth, such as an abnormally shaped uterus, can cause problems becoming or remaining pregnant.
Cervical stenosis, a narrowing of the cervix, can be caused by an inherited malformation or damage to the cervix.
Sometimes the cervix can’t produce the best type of mucus to allow the sperm to travel through the cervix into the uterus.
Unexplained infertility. Sometimes, the cause of infertility is never found. A combination of several minor factors in both partners could cause unexplained fertility problems. Although it’s frustrating to get no specific answer, this problem may correct itself with time. But, you shouldn’t delay treatment for infertility.


#35

Hey millie thanks for the useful information u gave .


#36

Seems I’ve already answered one of your posts, saying I got to know a lot about tubes blockage through Bio tex com youtube videos. As I’ve mentioned, Fallopian tubes can be damaged in many different ways. If the furthest end of the tube is blocked, then the tube cannot pick up an ovulated egg. This may also cause the tube to collect fluid and dilate, creating what is known as a hydrosalpinx. It is important to know if your blocked tubes created a hydrosalpinx, because the fluid that collects inside can decrease your chance of successful pregnancy with IVF by about 50%. If your doctor finds a hydrosalpinx, they may recommend that you have the tube removed or blocked using a surgical procedure, so that the fluid from the hydrosalpinx does not communicate with the uterus. Damaged fallopian tubes may sometimes be partially open. This can increase your risk of an ectopic pregnancy, or a pregnancy that implants outside the uterus. The fallopian tube is the most common place for an ectopic pregnancy to grow. An ectopic pregnancies can be dangerous if it grows large enough to cause heavy bleeding, and so in almost all cases it should be removed using surgery or medication.
The good news though is that blocked fallopian tubes prevent natural conception, but IVF can bypass the tubes. During IVF, the ovaries are stimulated to produce several eggs. The eggs are then retrieved using a short procedure under anesthesia. They are then fertilized in the laboratory. Created embryos are placed into the uterus through the cervix. so the fallopian tubes are bypassed all together.
Besides, I’ve shared the info on the innovative method the clinic offers these days. It’s called the mitochondrial donation. This method allows the patients who are above 40 and for those, who suffer from low levels of AMH, to conceive with their own eggs. How is this possible? - To carry out such a procedure, an egg donor with a high functional activity of mitochondria (a blastocyst production rate of 70% or more), a patient (willing to get pregnant), and sperm for in vitro fertilization are required. Healthy functionally active mitochondria are taken from a donor’s oocyte and integrated with the patient’s cells. Next, fertilization with sperm and transfer of a healthy embryo into the patient’s uterus is performed. Basically it’s the implantation of a healthy and functionally active donor mitochondria into the cells of an infertile patient, that provides the patient’s cell with the necessary energy and contributes to successful pregnancy.
Isn’t it amazing?! You use donor’s mitochondria only, which doesn’t affect the baby’s DNA at all. You use own egg with a new ‘‘power station’’. So the future baby’s completely YOURS!!