I am currently on Crinone. When you place in the applicator, don’t stick it all the way up because you can cause a lot of irritation… stick it in the “width” of two fingers, then squeeze. You shouldn’t just lay down or sit around after placing it in (if possible). It’s absorbed more quickly when there’s friction. So for me, I get up in the morning and put it in, then I’m walking around getting ready for work so it’s absorbed. After a few day of being on it, you will start to notice some white clumping inside and sometimes when you wipe. I initially thought it was a yeast infection, but my RE checked me out and it was just the build up of the crinone. So I usually clean it out at least once a day (when I’m in the shower). My RE said I can just kinda swipe around in there with my finger to get out excess clumping.