Depleting Ovarian Reserve & Anovulation


Hey everyone! I am new here… I have been trying to conceive for a year and a half with no success.

I tried Clomid and got huge cysts from it… I am now on my 2nd round of letrozole and just got a negative pregnancy test…

Does anyone have experience with this? Advice?


Hi! I do not have experience with clomid or letrozole or even cysts. But I have lots of experience with negative tests.
Have you been diagnosed? I’m guessing you are doing timed intervourse. Do you track your bbt? I know a lot of women don’t like to be bothered by it, but I highly recommend it to everyone.


Cysts are no good, honey…You should try to get rid of them.
Try a good consult with another dr first. Getting 2nd opinion will not make things worse. At least you might get more answers…Let me ask about your dx? How long have you been into this?
Here’s my background:
40 yo, dh - 42 yo. Married in 2013. TTC since 10/14. Dx: PCOS, blocked fallopian tubes. AMH <3.2. Tried acupuncture whilst infertility treatments. IVF 9/15 - failed. IVF 12/15 - failed. Dr suggested also PGD testing as I had mc. He suspected me of being a carrier of Wilson disease - very rare treatable disorder. OTD 5/16. 2 shots with a new clinic - bfp!
Hope this message finds you well.


Normal and regular ovulation, or release of a mature egg, is essential for women to conceive naturally. Ovulation often can be detected by keeping a menstrual calendar or using an ovulation predictor kit. There are many disorders that may impact the ability for a woman to ovulate normally. The most common disorders impacting ovulation include polycystic ovary syndrome (PCOS), hypogonadotropic hypogonadism (from signaling problems in the brain), and ovarian insufficiency (from problems of the ovary). If your cycles are infrequent or irregular, your doctor will examine you and perform the appropriate testing to discover which problem you may have and present the appropriate treatment options. I suffered from PCOS for such a long term. This was the monster of my infertility story. Till when I underwent surrogacy in Bio tex. I am now a proud mother. Hoping that things will work for you dear. All the best.


There are several clinical markers used to identify a “poor responder” well. Today the most commonly used is FSH. It’s a blood test drawn on the 2nd or 3rd day of the menstrual cycle. Unfortunately, test results may not be that accurate. 'Cause it matters when blood is actually drawn during the menstrual cycle. Ultrasound screening for ovarian volume and antral follicle count is a promising approach. With this technology patients are assigned to an appropriate ovarian response group (Based on follicle number.) A “poor responder” will have a lower chance of conception and live birth. (Compared to members of the normal responder group regardless of the age.) The problem is in assigning patients to the wrong response group on the basis of pre-treatment testing tough. That’s why it’s so important to get tested at this stage appropriately.