hi we are new to this site just wondered if anyone could give us some advice or help… my partner was diagnosed with y chromosome microdeletion of the afzc region we went through ivf using microtese but this failed has anyone gone through similar or would recommend a second try.
Since daughters do not inherit a Y chromosome from their fathers, they will not have any fertility or health problems themselves. The sons, however, will inherit the abnormality and, therefore, may also have the same type of fertility problems as their fathers. What about other health issues? Unfortunately, there haven’t been a lot of studies on the children born to men with these micro deletions. A study from 2011 found that some men with Y chromosome micro deletions also had abnormalities of another part of the Y chromosome (the pseudo autosomal regions or PARs). Abnormalities in one of the genes in this region, called the SHOX gene, has been associated with short stature, mental retardation, and arm and wrist deformities. More work needs to be done in this area. Men who have no sperm in their ejaculate which is not due to a known obstruction, should have Y chromosome micro deletion testing. In addition, men who have otherwise unexplained low sperm concentration (less than 1 million) should also be tested unless they have fathered children in the past without any fertility treatments.