Hey everyone. Looking for some insight as I’m totally lost due to poor fertilization report.
My husband and I have been TTC #3 for two years. We have two children together ages 4 & 5. Each were conceived naturally after 1 month of trying. Had a chemical pregnancy on a natural cycle about a year ago. We have done a couple IUIs with clomid/Femara, all BFN. We finally bit the bullet and moved onto IVF.
Stimming wasn’t uneventual. I started with 150 follistim and 10 low dose hcg for 5 days. My 5th day on stims ultrasound showed 11 measureable follices with 16 being the largest. Nurse called me in the afternoon on the 5th day after bloodwork results and instructed me to take a ganirelix immediately. She also upped my follistim to 225. I stayed on this combination (follistim, low dose hcg and ganirelix for another 5 days, so 10 days total of stims).
Every time, I went in for an ultrasound more follicles were measurable and all were growing nicely. The first snag occurred when the doctor called me on day 8 of stims and told me that we wouldn’t be able to do a fresh transfer because my progresterone spiked to 2.1. I was bummed, but was okay with doing a FET as my follicles were growing so nicely. I was worried about triggering too late, but he ensured me that I wasn’t ready yet as I had a good number of follicles (a few 16-18s, but most 12 and 13s), but not mature yet. I stimmed for 2 more days on same dosage except upped the low dose hcg to 15. Progesterone level remained the same. My levels at the day of trigger were E2: 2900, FSH 17, Progesterone: 2.1 and LH <1.
I just had my egg retrieval on Tuesday and the RE was so pleased to recover 22 mature eggs. He did tell my husband that something weird happened with my lining as it dropped to only a 4, but I wasn’t overly concerned since I was doing a freeze all. Still puzzeling why that would occur, but my husband and I were so happy until I got the dreaded phone call today to tell me that only 2 of the 22 eggs fertilized! We are in utter shock.
How could fertilization be our problem? We have two kids together, in which we conceived naturally quite easily. Because of that we didn’t do ISCI. My husband has had multiple semen analyses and they have all come back fine.
The embryologist is so puzzled. She said she sees the sperm swimming around, but there are no signs of fertilization and my eggs look good. I wish we did ISCI, but since there didn’t appear to be a sperm issue it wasn’t recommended.
Why didn’t they try rescue ISCI at that point? Has that ever worked for anyone here? Why would something like this happen? Poor egg equality? A sperm issue? Poor protocol? Did I stim too long and my eggs were fried? I’m just at such a loss. They will call me tomorrow to give me an update on if there was any late fertilizations. This is devastating to us, especially since we payed out of pocket for all of it.