[B]L[SIZE=2]ooks like high progesterone @ c2 can decrease chances of successful IVF… I need to make a decision about this… do IUI and risk waiting till march or go straight to IVF now and forget IUI since it looks like I can;t use the progesterone which I need…[/SIZE][/B]
BACKGROUND: The objective of this prospective study was to assess the impact of elevated serum progesterone levels on day 2 of the cycle on pregnancy rates in patients treated by IVF using GnRH antagonists. METHODS: Ovarian stimulation was started on day 2 of the cycle if progesterone levels were normal (normal‐P group, [I]n[/I] = 390). In the presence of elevated progesterone, initiation of stimulation was postponed for 1 or 2 days (high‐P group, [I]n[/I] = 20) and was started if repeat progesterone levels returned to normal range ([I]n[/I] = 16). Stimulation was performed with recombinant FSH (rFSH) and GnRH antagonist was always started on day 6 of stimulation. RESULTS: A significantly higher exposure to progesterone and a significantly lower exposure to estradiol was present in the high‐P as compared with the normal‐P group from day 1 to day 8 of stimulation. In addition, a significantly lower ongoing pregnancy rate both per started cycle (5.0% versus 31.8%; [I]P[/I] = 0.01) and per embryo transfer (6.3% versus 36.9%; [I]P[/I] = 0.01) was present in the high‐P compared with the normal‐P group, respectively. CONCLUSIONS: The presence of elevated serum progesterone on day 2 of the cycle is associated with a decreased chance of pregnancy in patients treated with rFSH and GnRH antagonists.