[quote=Jennjack11]I just got a call from my clinic they are adding Letrozole to my protocol.
I did long lupron last time and only got 7 follies. I was on 450 IU Follistim
I asked to be switched this time, so they put me on the angtonist protocol as follows:
Then when I get above they add the Garilinex to the mix.
My question is I have heard that with clomid, it ruins your lining so a lot of times they have to do a FET. I know Letrozole is supposed to be similiar, would this hurt my lining? Last time my lining was great. Will this impact it to where it may not be so great and a FET may be in order? Just curious! thanks all:grouphug: :grouphug:[/quote]
They are different. Letrozole suppresses estradiol production. Clomid is an estradiol receptor blocker. Both cause the pituitary to release more FSH. They do this because the hypothalamus will release more GnRH to stimulate the pituitary when it senses less estradiol.
I have heard that Clomid does harm the endometrium, but that letrozole does not. I’m not sure what evidence there is for these conclusions.
The letrozole will work up until you start the ganirelix. They will probably have you discontinue the letrozole when you start the ganirelix. Ganirelix is a GnRH antagonist, and therefore immediately shuts down the pituitary, so letrozole cannot stimulate the pituitary in the presence of ganirelix.