I know I am homozygous for A1298C - had spina bifida in utero but closed over before I was born. I’ve been encouraging my sister to get tested because her and her husband are going to be trying for #2 soon. She called her doctor to see about getting tested and he doesn’t think she needs to be tested as if they find out anything the only thing that could be done is to take folic acid. My RE put me on a prescription supplement that gives me 5000mg folic acid/day - over the counter prenatals only have 800mg.
So question is because I am homozygous for this gene wouldn’t my sister also have a chance of having this gene - maybe not homozygous but maybe heterozygous?