Next IUI or IVF?


#1

I am planning on going for IVF on next January after trying to
conceive naturally and 2 failed IUIs.
Please advice me with any recommends before attempting this step. As I don’t have anyone to advice.

Here is my story
Age : 30 at present
——------Married in 2014 —————
Got naturally pregnancy in 2014 but had a manual abortion (due to some
personal family problems )
————2015-2016 ------------------
Tried naturally from 2015-2016 >>> No Pregnancy
————Visited fertility clinic ——-
OB doctor asked us to visit fertility clinic after trying to conceive
naturally. Below are the process doctor followed
Step 1 : just Clomid medicine for 2 cycles >>> No Pregnancy
Step 2 : Clomid with Ovidrel for 2 cycle >>> No Pregnancy
Step 3 : Clomid , Ovidrel & IUI >> Pregnant but ended with
miscarriage on 3 month
Step 4 : Clomid for 2 cycles >>> No Pregnancy
Step 5 : letrozole, Ovidrel & IUI >>> No Pregnancy
Step 6 : ??? ( IVF or IUI )
---------------Health conditions-----------------
Prolactin harmone elevated >> Had MRI and started taking Bromocriptine
Thyroid >>> they found thyroid after first IUI since then started taking Synthroid
---------------------Prescription-------------------
Bromocriptine
Synthroid
Metformin
Prenatals

My Husband story :

Age 33

--------------------------------Testosterone --------------

Testosterone Total(Adult Male ) 504.38ng/dl Normal Range: 205.00-781.00 ng/dl

--------------------------------Semen Analysis--------------

Below is the Semen Results during 2 IUI

Volume > 1.8 ml

Sperm concentration >> 177.5

Total Sperm count >> 319.5

Progressive Motility >> 37 %

Non-progressive Motility >> 3%

Inmotile >> 60 %

Total Progressive Motile Sperm >> 118.2 x 106

Any suggestions are welcome.

Thanks


#2

Oh my, that was quite detailed. I’m afraid I don’t have accurate answers for you. We started with IVF yrs ago. Passed 4 rounds with OE and DE. Last unsuccessful one in June resulted in the early mc. Our final shot with donor egg brought success. I’m currently prego with a LO. Waiting for the 7wks scan. So from personal experience, he initial step in the IVF process is to undertake an advanced ultrasound scan. This scan is vital. Dr explained it is a key part in deciding on the treatment protocol. The imaging of the ovaries allows them to assess ovarian reserve by counting the small growing follicles. In addition they measure blood flow in the ovaries which also checks fertility status. Well, I’m not sure IUI is going to be the your another step. You’ve had them just enough. So probably it’s time to opt for IVF. Not insisting though…


#3

Thanks
Do you suggest any lab works I need check apart from above information before IVF or we need to improve in any other areas ?
We are so concerned because when ever we are visiting doctor she says the health conditions of both are good but we are ending up with no success in every step.


#4

Hello, honey. That must be frustrating! I’m sorry they cannot find the exact reason why it’s not happening…One can call me ‘‘experienced IVFer’’ because we experienced 2 failed IVF cycles with own egg and 1 failed IVF with donor egg. Yet one successful resulting in my baby girl. I was 40 yrs young when we first came in terms with fertility issues in me. It was pcos and blocked fallopian tubes. Later adding low AMH and dr suspected me to be the carrier of Wilson disease, so wanted us to do PGD testings on embies. Thankfully it became out of the question with me. I’ve read your background and i’m sure I cannot give you some valuable advice for your very situation. But looking onto things I’d go straight to IVF. Has your dr considered ICSI? I believe if a perfect spem is injected directly to a perfect egg - then it must work! Or while IVF when some good quality embies are cultured in the lab and put inside…My position is that I wouldn’t go for IUI being in your shoes. The choice’s always your though. Wishing you the best of luck!


#5

Congratulations!! :hugs:
I know how tiring this road might be. And often we get things quite not expected. Then find ways to deal with the issues and finally end up with an amazing LO inside. Wanted to ask you how are you feeling? Is the pregnancy being smooth for you? I mean the symptoms or any other interesting things you’ve experienced? I’m a mom of a wonderful DE IVF baby girl. I remember I was getting very down at times. My pain in left ovary was so intense. Not saying due to pregnancy. I’ve always had pcos and probably some meds side effects. Also nausea, dry heaves and very dizzy, etc, Just wanted to know is that normal for others who’ve been through the same treatment? My body was very reluctant to any of good changes. I appreciate you have any words of experience.


#6

I guess that’s it. I’ve been like you through the donor egg ivf. But I truly think the prego symptoms don’t depend on the type of treatment :joy: I know just the emotional side of the coin. So probably it’s sth very similar to those symptoms you experienced. I had some pinkish spotting and some brown discharge after it. A bit of headaches, was very tired at times. Sore boobs and to painful to even touch. Ladies experience all different. Hope you’re well. Keep up posting.


#7

Hi, I’m sorry to hear about your struggles. When a woman has her fallopian tubes blocked, the sperm cannot reach the egg, and therefore fertilization cannot take place. In other words, if the sperm never meets the egg, pregnancy will never happen. The most obvious symptom of blocked fallopian tubes is therefore anovulation (no egg is released monthly). Depending on the cause, one treatment may work better as others. Blocked fallopian tubes may be caused for the following reasons: STD infection, uterine infection caused by an abortion or miscarriage, history of a ruptured appendix, history of abdominal surgery, ectopic pregnancy, surgery involving the tubes, and endometriosis. The potential treatments for blocked fallopian tubes are laparoscopic surgery and IVF when repair surgery doesn’t work. Talk with your doctor for further advice. I hope I have been able to help.


#8

IUI is recommended in case of male issue. - Low motility or count of swimmers, you know. Then sperms are washed in the lab. They’ll use the best for the fertilization. It’s less invasive than ivf. Obviously because you’ll not have to retrieve your eggs and then fertilize them with your partner’s sperms. and then (if lucky) insert your embies into the womb by means of a catheter…This is purely an individual decision based on a particular case circumstances.


#9

Coming here for updates. How are you currently doing honey? Have you found the solution?
I have turned down many baby related events over the years. hubby has gone alone sometimes.He never pushed me to go if I felt uncomfortable. We just kept communicating together and came out of this journey stronger.It wasn’t easy the hardest thing I’ve ever done. and there were many bumps along the way but we got there eventually 7 years later. I’m so glad we didn’t give up and kept going. This site also supported me through some truly awful times and so grateful for it. Never be sorry for needing to get things things off your chest, much worse bottling up. Whatever your path is, please, remember what you’re doing this for. Stay strong and brave. Maybe this link could be helpful, just have a look: https://biotexcom.com/a-unique-method-to-get-pregnant-in-your-40s-with-your-own-eggs/. Good luck for your appointments. hope all goes well. Keeping everything your time will come soon Xx


#10

This is my story. Me 40; DH 45. DX - PCOS, endo, one ovary and tube; MFI. Oct 2008: Mike is here! 7lbs 14oz, 20.75 inches; C-Section.
TTC #2 since Sept 2015. BFN= 3 IVFs. IVF#4 – early mc @6w4d, June 2018. Last IVF #5 (5dt of two 2AA blasts) – BFP!!
Beta #1, 11dp5dt= 295.
Beta #2, 13dp5dt= 825 (doubling time of 32 hours!); progesterone 130.
Last time we were using donor eggs at Ukrainian clinic bio tex com. Quite far away from home. But the clinic was doing its best to make our stay with them comfortable and the most effective.
Unless you feel good about using your repro center, do follow all dr’s recommendations! He does know your case the best! Well, doing injections is really horrible, but for the first timer it could be even more. In case you’ll choose going through IVF here are some of the tips to ease the pain of the dreaded progesterone injections. First, warm the progesterone either to a comfortable room temperature or body temperature. You can also prepare the site of the injection using ledocaine but it requires a doc’s prescription.
Then this is good to learn to relax muscles. If you have help, lie flat on your stomach, with toes inward. Another method is to stand up against a table or other support, with your leg bent, relaxing the muscle, while someone else gives you the injection.
Then the injection itself. Keep the dry skin tight and smooth. Try to insert the needle into the skin quickly. After injection’s done massage its site. After about 30-60 seconds apply hot water bottle and continue massaging area. Also keep warm compress further.
Hope this helps. We’re all here for you, just drop a line in case you feel confused etc. Blessings.


#11

You should consult the best infertility specialists first. They will understand it well and provide you the best fertility treatments.


#12

Hi everyone. I’m sure this purely depends on a clinic/country. One should look not for low prices first, but for success rates. Sometimes paying much does not mean you get the best of servces and care. Of course another question is the toughness of the case. So that a clinic does its best to offer the best options for its clients. Mine, for example, treats even the toughest cases. We chose them mostly for their high success rates and loads of good reviews on European sites. We’re happy parents after IVF#2 (DE) successfully preformed.


#13

On the day of my last retrieval I received a prescription for Tylenol #3 with codeine for pain. It was vital to eat a small meal or snack before taking pain medication. Because narcotics can make you very nauseous if taken on an empty stomach. My doc told me it was normal to expect abdominal cramping and bloating for up to a week after retrieval. And that the severity of symptoms can vary greatly between patients. It may take a couple of weeks for the ovaries to return to normal size. BUT if bloating and discomfort increases over the 7-10 days after your retrieval, you should let your nurse coordinator know immediately. Our last results: eggs retrieved - 20, fertilized 10.


#14

Hi all. I just wanted to add some of the info on mitochondrial donation option. I made a bit more research on the point, and got even more links…The procedure isn’t still widely used, but the clinic we’re with does use this method currently. As I’ve told previously, nowadays women over 40 who had multiple failed ivf cycles can get prego and carry a genetically related baby. This is possible through the mitochondria donation treatment. Those are just some general facts one isn’t usually aware about. Mitochondria convert nutrients into energy. This very energy is needed to manage many processes in organism. A mitochondrion provides energy needed to ensure effective functioning of organs. There is often a decline in mitochondria function in oocytes of women 40+. That can be the reason for implantation failure. Mitochondrial disfunction can lead to multiple failed IVF cycles. This is how the things are going on. Healthy mitochondria are retrieved from a donor’s egg and transferred to a patient’s egg. Then the oocyte is fertilized and a healthy embryo is transferred into a patient’s uterus.
A mitochondrial donor IS NOT A GENETIC PARENT of a future baby!!! Donated mitochondria account for less than per cent of the baby’s DNA!!! One more important thing is that women who donate their mitochondria will not have any rights for the baby!!! Mitochondrial donation is anonymous.
No doubt, infertility is a global health issue that is breaking records… Surrogacy and egg donation treatment are becoming first choices for women. And mitochondrial donation makes it possible for a woman to carry and give birth to a child genetically related to both parents on her own. Three-parent baby program allows thousands of infertile women all around the world to carry and give birth to genetically related to them babies. In Ukraine, for example, only one clinic provides such programs. The package costs depend on the number of attempts. Also the prices for mitochondrial donation programs are inevitably increasing. I know for sure that in August the prices are the following: 6500 EUR - 1 shot with mitochondrial replacement. 9900 EUR - 2 shots. 14900 EUR - 5 shots.
I believe every other method should be tried before moving onto more invasive treatment procedures. Hope this is helpful.


#15

My cardial congratulations on your success!
Mitochondrial replacement therapy is one of the innovative methods to treat infertility. This option is relevant to women over forty years old who have treated infertility with no luck. In the most of cases women have a low functional activity of mitochondria. And those in their turn are the most important components of any cell. Therefore, it’s an opportunity for a woman to give birth to a long-awaited baby. Moreover, this baby will have a genetic connection with her and her husband/partner! Mitochondria are often called “cellular power plants”. It’s so because of their ability to convert nutrient molecules into energy. Mitochondria provide eggs with the necessary energy for normal functioning. A woman facing the constant failure, needs to restore the mitochondria of oocytes first of all. Taking into consideration the number of eggs decreases with age. If there are not enough functionally active mitochondria in the eggs, then it is possible to become a mother using mitochondrial donation + IVF. Fertility specialists find an egg donor with high functional mitochondrial activity. These healthy mitochondria are taken from the donor’s egg cell, integrated with the patient’s cells, then fertilized with the sperm of the husband/partner. A healthy embryo is then transferred to the uterus. 1 shot of mitochondria donation + ivf, for example at our clinic, costs 6500 euros.
We passed de ivf treatment plan abroad, in Kiev (They didn’t conduct such programs then!). Here are some of their really strong sides. Their embryologists work with fresh genetic material (eggs/sperm cryopreservation is used only at patient’s will). It is known and proven that quality of eggs gets worse during the freezing process leading to the failed IVF attempts. In addition to the spermogram doctors there conduct sperm analysis for apoptosis. Conducting this medical test embryologist determines presence of the damaged sperm cells which prevent successful conception and can cause child’s DNA damage. In the case of cells’ poor quality, doctor prescribes appropriate medication, afterwards performs reanalysis and successfully fertilize the egg. Karyotype analysis is the part of a standard analyzes set (karyotype test shows the total number of chromosomes, the sex of the person being studied, and if there are any structural abnormalities with any of the individual chromosomes which can cause child’s diseases). They can also calculate the ideal ‘window of implantation’. This is the most successful period for the embryo transfer without disturbing its structure and endometrium integrity. Their medical staff carry out detailed diagnostics of patients in order to identify clearly the seeds of the disease or reasons of the unsuccessful IVF attempts. There are no identical protocols!! They walk the line of the latest methods of treatment. So, for example, embryologists use the most successful method of working with blastocysts, namely, embryo transfer on the fifth day. Or they’re currently widely using the mitochondria replacement therapy with ivf which is aimed to supply the eggs with the needed energy for successful fertilization. Definitely worth looking onto!


#16

I was told that our clinic is one of the more expensive ones in the area. because they have very good stats and use the latest tech to assist hatching and freeze embryos. I’m sure there are more scientific terms than what I used. I also know they recommend PGS testing. also as you can see from the total costs attached, it’s included whether you ultimately choose it or not. Or you can view it as having to pay a penalty if you don’t do PGS! But I wanted to attach the total bc your overall might be lower. will add that many of the doctors there were faculty at medical school so they really valued research, problem solving, and teaching… I’ve never once felt it was all about money or that they didn’t care. I did feel I was in the best hands. Then again, I didn’t have a comparison basis – because we didn’t have great outcomes with previous 2 IVF cycles – both ended in mc. However, we’ve been at this for years!! I have adenomyosis, LOW AMH. I’ll take a lot of responsibility for my poor egg quality…No one needs or deserves to have bad experiences with the clinic while going through this process. It’s all out of our hands so let’s pray for the best. Just imagine all our embryos hatching…


#17

My husband and I have been struggling to have our baby#1 for years. After a year of unsuccessful trying we finished the work up at the RE and discovered that my AMH was really low - 0.07. I did end up pregnant once. but it was a chemical that ended just shy of 4 weeks. The RE basically said that I had a 4% chance of getting pregnant naturally. Moreover, if I do there is a 50/50 chance of miscarriage due to DOR and poor egg quality. I am currently almost 41. I’ve never had children on my own before. But due to circumstances adopted my niece time ago… So during our further investigations our RE said that our best chance was to do IVF with pregenetic screening. He said that bumps are chances up to 60%. This seemed too little…But we made the go. I think I’ve got the best prepared for IVF cycles – used all the possible tips to make my eggs better and the overall health state just excellent…We got bfp twice, and twice miscarried…Such a heartbreaking experience!! Finally, after more investigations done, were said it was not going to happen to us…So that we should apply for surrogacy. Chose Ukraine, BioTexCom, were passing standard package with them.


#18

To me personally as for a new IVF’er doing injections was really horrible, but for the first timer it could be even more. So here are some tips to ease the pain of the dreaded progesterone injections. First, warm the progesterone either to a comfortable room temperature or body temperature. You can also prepare the site of the injection using ledocaine but it requires a doc’s prescription. Then this is good to learn to relax muscles. If you have help, lie flat on your stomach, with toes inward. Another method is to stand up against a table or other support, with your leg bent, relaxing the muscle, while someone else gives you the injection. Then the injection itself. Keep the dry skin tight and smooth. Try to insert the needle into the skin quickly. After injection’s done massage its site. After about 30-60 seconds apply hot water bottle and continue massaging area. Also keep warm compress further. These tips helped me.