I’m on the progesterone 2x per day (vaginal inserts) and have wondered about it myself since my RE never tested my progesterone levels until after my BFP (and even then only b/c I asked the nurse to do it!). I know if you don’t have enough progesterone early in the pregnancy it can lead to a miscarriage, so I always assumed my RE’s theory was ‘better safe than sorry’. I think I started the day after my IUI.
I found an interesting article on the subject. Click HERE, but here are some excerps from it. It seems progesterone is required after IVF:
[FONT=arial][B]Luteal phase support with progesterone in IVF[/B][/FONT]
[FONT=arial]Progesterone prepares the endometrium for embryo implantation and maintains it in a state that can sustain pregnancy. In women undergoing controlled ovarian hyperstimulation (COH), progesterone supplementation during the luteal phase is required to [/FONT][FONT=arial]support corpus luteal function. COH is part of the IVF regimen where exogenous gonadotropin such as recombinant follicle-stimulating hormone (rFSH) (eg, follitropin alfa filled-by-mass [Gonal-f® FbM], Merck Serono) is used to stimulate follicular development in the ovaries.[/FONT]
[FONT=arial]“The reason is that after COH, there is usually a fairly high level of estradiol, which inhibits endogenous secretion of luteinizing hormone [LH]. Without adequate LH, the corpus luteum may not produce enough progesterone to support the luteal phase,” explained So. “Thus, all women undergoing COH need luteal phase support with progesterone regardless of whether gonadotropin-releasing hormone agonists or antagonists are used to control inappropriate LH surges that lead to premature ovulation. This is now an important part of the IVF regimen.”[/FONT]
[FONT=arial][SIZE=2]For IUI, their study showed a higer pregnancy rate when using progesterone. [FONT=Georgia][FONT=Arial]From the report[/FONT] "[FONT=arial]If you perform ovarian stimulation in IUI, you probably need luteal phase support with progesterone. Otherwise, pregnancy rates may be compromised because the endometrium may not be favorable for implantation and for the pregnancy to [/FONT][FONT=arial]develop” [/FONT][/FONT][/SIZE][/FONT]
[FONT=arial][SIZE=2][FONT=Georgia][FONT=arial]Personally, I agree with the others on playing it safe. I would hate to get a BFP and have it fail b/c of progesterone problems. [/FONT][/FONT][/SIZE][/FONT]