I am starting my 6th fresh round of IVF the end of June/beginning of July. I have been diagnosed with high FSH (highest recorded was 20 when I was 27), low AMH (1.56), DOR. Basically, I have crappy eggs. I have stimmed well in the past. My last cycle I had 19 eggs retrieved. However, only 11 were mature and only 5 fertilized. In past cycles, I have had as many as 24 eggs retrived and as little as 11 eggs. We always use ICSI and they usually fertilize well. Not sure what happened last time. I was taking DHEA for 3 months prior to my last cycle hoping to improve egg quality…maybe it made it worse. I have since stopped taking it and have continued my other supplements (Super B complex, baby asprin, coq10, vitamin c, pycnogenol, myo-inositol, probiotic, wheatgrass, red raspberry leaf, vitamin d, fish oil, l-arginine, prenatal)
I conceived a healthy baby girl born in 2010 after the Microdose Lupron Flare protocol. I had a 3dt transfer of 2 6 cell, 1 5 cell and 1 4 cell embie. She was one of those. I have been pregnant twice since using the antagonist protocol…300 Bravelle, 300 Menopur, and Centrotide. Both resulted in miscarriage. I have had plently of negative cycles as well.
After regrouping from our last failure in March, my RE decided to switch things up completely. We have tried recreating the protocol that made my daughter, without success. I seem to get more eggs from antagonist protocols, but still have poor embie quality and have never had an embie go to day 5. I have always had 3 day transfers. So onto a new plan.
My RE now wants to do Estrogen Priming with an Antagonist Protocol. I will start Estrace in the luetal phase of my period as soon as :af: arrives. Then once :af: arrives again, I will start stimming. I will be on Follistim 375 units, Low Dose HCG 10 units, Ganeriellix…and Letrozole in the beginning of my stim phase. I have never used any of these meds and am especially worried about the letrozole. What is its purpose? What are they hoping to acheive by adding it to my protocol? Can it help improve egg quality? I did ask them and they said that they wanted to “change the environment” in hopes for better quality eggs. They are afraid they are “frying” my eggs with too much menopur/bravelle. I know Letrozole can be used to prevent OHSS because it keeps E2 levels low…but I have never been at risk for OHSS…my E2 levels are usually around 2400 after 11 days of stim.
Needless to say, we are rapidly reaching the end of our financial and emotional rope. Does anyone have any experience using this type of protocol with Letrozole? I know I tagged Ghost in my Thread title…but anyone with experience would be helpful.
Thanks, ladies and :bsv: to all of you.